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Are Drakons superior beings? in Geneforge 4: Rebellion
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Member # 869
Profile Homepage #389
quote:
Originally written by Lord Safey:

Second the unbound is a product of the Rebellion not the Drakons alone. If you read the trakovite ending where you destroy their equipment but still make one generation of Unbound you find out that the drakons can't make another generation because the rest of the rebillion refuses to help them.
No they didn't; they refused to let them. There's an important difference. The human rebellion didn't even know of the Unbound's existence until they were almost complete.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Perfecting items in Geneforge 4: Rebellion
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Member # 869
Profile Homepage #2
quote:
Originally written by Schrodinger:

Try using the elixir on a belt, shoes, or a shaped fiber cloak.
Don't forget gloves. The Gloves of Savagery are the first really good artifact you can make.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Now is the time ... in General
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Member # 869
Profile Homepage #90
quote:
Originally written by Drew:

do you really think you have the knowledge to make such determinations
Why does the fact that I lack the knowledge to make a good decision give anyone else the right to make it on my behalf?

I don't object to an independent organisation testing drugs based on its own standards of safety and efficacy. What I do object to is that organisation having the right to ban anything that doesn't meet its standards. Suppose that the FDA didn't have that power; if you wanted, you could choose to only buy drugs that had the FDA seal of approval, and get exactly the same result as under the current system.

[ Monday, April 02, 2007 23:33: Message edited by: Thuryl ]

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Are Drakons superior beings? in Geneforge 4: Rebellion
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Member # 869
Profile Homepage #348
quote:
Originally written by Stillness:

The issue is skill. You can't reason away the simple fact that the drakons have 'far more skill' than monarch. The game says it. Case closed.
It's worth keeping in mind that the game says this before the PC can have access to the Sealed Catacombs, so the PC doesn't yet know the full extent of Monarch's skill at that stage.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Now is the time ... in General
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Member # 869
Profile Homepage #86
quote:
Originally written by Drew:

In the very least, Thuryl, I don't think you can argue against an "effective" requirement for medications before they're marketed. Look at the alternative - the dietary supplement market. Statutorially protected from the FDA, it's a multibillion dollar industry that is based largely on anecdotal evidence of effectiveness and frequently outright fraud in marketing.
The very fact that it's a multibillion dollar industry and that the anecdotal evidence exists suggests that all those supplements are doing something for the people who buy them, even if it's only providing psychological comfort. We all need our placebos, and it's not always wise to investigate them too closely lest they stop working.

I can and do argue against an effectiveness requirement, because it's impossible in principle to prove or disprove effectiveness with certainty, and I don't trust the FDA to decide how much evidence is enough; I'd rather make that decision for myself.

(I suppose you're going to ask me whether I think I know better than a panel of experts; that's entirely beside the point. Would you have every family's budgeting and investment decisions made for them by a panel of economists? Protecting people from themselves is ultimately futile, and unlikely to inspire gratitude.)

[ Monday, April 02, 2007 05:47: Message edited by: Thuryl ]

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Useful creations/spells in Geneforge 4: Rebellion
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Member # 869
Profile Homepage #4
quote:
Originally written by Sir Spiff:

If you're going purist pro-shaper, i.e. no canisters, then the only ultimate creature you can get is War Trall, which is pretty good when it has no competition on its own tier.
As far as I know, there aren't actually any trainers who train you in Create War Trall -- Shaper Grim doesn't, at any rate. It'd certainly make sense if it were the only "legal" creation of its tier, but it isn't.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Now is the time ... in General
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Member # 869
Profile Homepage #82
I just don't see why the FDA should default to banning a drug unless it's proven safe and effective. The criminal justice system doesn't default to imprisoning people unless they can prove their innocence.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Now is the time ... in General
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Member # 869
Profile Homepage #80
quote:
Originally written by Randomizer:

The FDA allows drugs that are only marginally better or sometimes worse than placebos into the system. Their availability means that people get them because of manufactuers pushing them instead of better alternatives. If the FDA kept them out of the system in the first place, then they won't be causing problems.
You acknowledge that the FDA allows plenty of bad drugs onto the market. I've provided evidence that the FDA keeps plenty of useful drugs off the market. Given the resounding lack of evidence that the FDA is competent to decide what's a good drug and what isn't, why have an FDA at all?

Arguing for the FDA to be made better rings hollow. The FDA can't be made better, because what it's trying to do -- distinguish between useful and useless drugs with 100% accuracy -- is fundamentally impossible. It can either raise its standards and keep more good and bad drugs out (for whatever definition of "good drug" you wish to use), or lower them and let more good and bad drugs in; what it can't do is simultaneously achieve both.

Besides, there's no objective standard for deciding what counts as a good or bad drug. A drug that's worse than a placebo for 99% of the patient population may be substantially better for the other 1%; statistical analysis tends to overlook that sort of thing, but it makes a pretty big difference to that 1%.

[ Sunday, April 01, 2007 19:46: Message edited by: Thuryl ]

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Are Drakons superior beings? in Geneforge 4: Rebellion
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Member # 869
Profile Homepage #321
quote:
Originally written by Retlaw May:

Beauty is in the eye of the beholder.
You mean the gazer. :P

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
I'm stuck! please help! in Geneforge 4: Rebellion
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Member # 869
Profile Homepage #7
If you still have a backup savefile in Northforge Warrens, you can try killing all the Shapers there instead of going back and getting reinforcements. It's significantly harder.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Info on Upcoming Scenario in Blades of Avernum
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Member # 869
Profile Homepage #8
quote:
Originally written by Excalibur:

"Wall ogres" sounds kind of cheezy, but I like the custom graphics. Keep up the good work.
:rolleyes:

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Now is the time ... in General
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Member # 869
Profile Homepage #75
quote:
Originally written by Randomizer:

Even when drug manufactuers disclose adverse side effects, they do so in a manner to minimize them. Saying that the effects are only temporary without mentioning that this applies to very short term use and not the long term use that they push for treatment. That the chance of occuring is subdivided into enough catergories to get below 1%.
So change the disclosure rules. Requiring side effects to be categorised by the organ system they affect would be a simple and non-arbitrary way to minimise the number of categories and get a reasonable measure of the overall risk of adverse effects.

In the end, the best defence against disinformation is word of mouth. If you want to know people's experiences of a drug, find and talk to a few other people who have been on it. Support groups are a good way to do this.

quote:
Also you can get placed on a drug with adverse effects against your will and/or legal directive by court order or doctor's order in a hospital or nursing home. Try getting someone off when the drug is not working and there are very obvious adverse reactions occuring.

I took one relative out of a nursing home after having this happen. One of the drugs had an FDA warning to discontinue immediately because of health risks if it wasn't working. Since it was an anti-diarrheal medication it was very obvious that it was having no effect. The others were causing brain damage.
The problem here, surely, is not the regulatory system but the fact that people can be medicated against their will. You can't very well defend the FDA by citing examples of bad things that are happening despite the existence of the FDA.

[ Sunday, April 01, 2007 14:35: Message edited by: Thuryl ]

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
To SW's Italian-speakers in General
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Member # 869
Profile Homepage #3
quote:
Originally written by Redstart:

Apparently the film's Italian title is "Mia moglie è una pazza assassina?", if it helps at all.
Hmm. Not as operatic as I might hope, but I think I can do something with that. Thanks!

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
To SW's Italian-speakers in General
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Member # 869
Profile Homepage #0
Could someone provide an Italian translation for the film title "So I Married An Axe-Murderer"? If possible, make it sound like it could plausibly be the title of an opera. It would be much appreciated.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Now is the time ... in General
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Member # 869
Profile Homepage #72
quote:
Originally written by Hawkwind:

quote:
If the drug contains what it claims to contain and isn't contaminated with anything else, and all known adverse effects are disclosed, the manufacturer shouldn't be liable for what happens to people who take it.
Thuryl, would you apply the same reasoning to cigarettes?

I would, and I'd be in good company in doing so; again, the entire legal basis for lawsuits against tobacco companies has been that they attempted to deceive the public about the dangers of their product. If they'd been upfront about the risks as soon as they discovered them, the lawsuits wouldn't be happening. (Of course, they'd also have sold fewer cigarettes.)

Of course, with cigarettes there's also the complicating issue of passive smoking, but it's the responsibility of the user rather than the manufacturer to use cigarettes only under circumstances where that won't be a significant issue. In circumstances where normal use of a drug will inevitably affect others besides the user, such as antibiotics (where every time someone uses an antibiotic, an opportunity is presented for antibiotic-resistant bacteria to proliferate, making that antibiotic less useful in future), I think there's a good case to be made for regulation.

On a side note, I wonder what it says about the community here that I always get more criticism when I advocate a position that isn't obviously evil.

[ Saturday, March 31, 2007 23:00: Message edited by: Thuryl ]

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Now is the time ... in General
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Member # 869
Profile Homepage #69
quote:
Originally written by Student of Trinity:

Hmmm; isn't liver failure apt to be a progressive thing? If 1% of people develop it after X months on the drug, doesn't that mean that more and more people will develop it the longer they stay on it? And liver failure is pretty nasty.
Not necessarily. With many drugs, liver failure is idiosyncratic; some people can experience life-threatening liver failure after a single dose (although this is rare), while other people can be on the same drug for years and have no problem. In any case, liver function is something that can be monitored and a patient can be advised to try and switch to a different drug if signs of trouble appear. If no other suitable drug is available, the patient might want to continue to take the risk -- if so, it's on their head (or their liver).

I think there is a place for safety and efficacy testing -- governments probably shouldn't be funding medical treatments unless there's reasonable evidence that on average they produce more benefit than harm. But if someone chooses to pay for a drug themselves and accept the risks, I don't think it's anyone else's place to stop them.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Now is the time ... in General
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Member # 869
Profile Homepage #67
quote:
Originally written by Drew:

It's unfortunate, but one-size-fits-all serves the most people with the greatest need. At least FDA has attempted to meet the needs of individuals with rare diseases; FDA offers ridiculous periods of marketing exclusivity for companies willing to develope "orphan drugs." Until pharmaceutical manufacturers are motivated by something more magnanimous than profit - and that's going to be a long wait - we're going to have to make due with the initiative they take, combined with what incentives the government can provide.
It'd certainly be easier to get new drugs to market if safety and effectiveness requirements were laxer. If a disease only affects a couple of thousand people worldwide, is it really still worthwhile to go through a 10-year process of clinical trials on hundreds of animals and people to prove the safety and effectiveness of a drug to treat it? Wouldn't it be better to test it in the field, as it were, and maybe arrange some follow-up studies to see what happens? Medicine is not pure science -- sometimes, getting a drug, any drug, out to people who need treatment and have none is more urgent than knowing for sure whether it works or is safe.

quote:
As for pulling lifestyle improving-yet-threatening drugs off the market: what are you talking about? Vioxx?
Are you familiar with pemoline? It's a drug formerly used for the treatment of narcolepsy and ADHD; a significant minority (tens of thousands) of sufferers of both conditions found that it was the only drug that relieved their symptoms without intolerable side effects. Unfortunately, there have been a couple of hundred cases where it's caused serious adverse effects including about 20 cases of liver failure. Its leading name-brand manufacturer pulled it from the market in 2005, and manufacturers of generic equivalents were soon forced by the FDA to follow suit.

Narcolepsy support groups and noted SF author Teresa Nielsen Hayden (who is narcoleptic) have campaigned for the ban on pemoline to be overturned -- the very people who were "protected" by the decision to ban this drug are the ones who want it back on the market. Some patients have turned to illegal and even more dangerous amphetamine derivatives for relief, as no legal drug adequately relieves their symptoms now that pemoline is no longer available. Not a regulatory success story.

quote:
It's all well and good, until the patient dies and the family takes action on behalf of the estate. Never pretty, and Merck is getting hosed for it. The alternative is for Congress to make the corporation immune to liability, and that's a horrendous slippery slope to start down.
If the drug contains what it claims to contain and isn't contaminated with anything else, and all known adverse effects are disclosed, the manufacturer shouldn't be liable for what happens to people who take it. Admittedly, those are some pretty big "if"s (especially the last one -- Merck was sued, after all, because of accusations that it was hiding what it knew about Vioxx's risks), but giving consumers the option of using a risky or untested drug at their own risk is better than banning it outright.

If the public have an unreasonable expectation that every drug on the market is going to be safe and effective, that's the public's problem. There is simply no way to guarantee that any drug will be safe or effective for a particular patient. If the safety and effectiveness requirements applied to drugs were applied to household tools, foods or practically anything else, half the stuff we use every day would have to be banned. The entire health food industry would be shut down if it had to prove all the claims it made with the same rigour as the pharmaceutical industry is expected to. Maybe that's what you want, but I don't think it's what the people who are actually consuming health food and thus affected by any such ban would want.

[ Saturday, March 31, 2007 18:41: Message edited by: Thuryl ]

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Music in Avernum in Avernum 4
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Member # 869
Profile Homepage #1
Jeff doesn't like music in games. He especially doesn't like music in his games. It bloats download size and he finds it distracting. Music is not likely to happen.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Rats Aplenty: passing the gates ... how? in Blades of Avernum
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Member # 869
Profile Homepage #5
quote:
Originally written by Meter Maid:

Actually, if the rat-you-cannot-stop is a bug - it's a very fitting one (Who will survive mankind? Rats, arthropods and bacteria ...).
It's not a bug, exactly. It's a puzzle. The fact that you got across without solving the puzzle is the bug.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
My game and editor keeps crashing, can anyone help? in Blades of Avernum Editor
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Member # 869
Profile Homepage #4
And also, PPC or Intel Mac?

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Has anyone tried this? in General
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Member # 869
Profile Homepage #7
Hey, if you're going to start trying recipes recommended by some guy on the internet, hit me up for a tabbouleh recipe sometime.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Now is the time ... in General
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Member # 869
Profile Homepage #65
quote:
Originally written by Drew:

How about your medications? Thanks to the FDA, you can be 99.9% certain your remedies aren't anything more than snake oil.
An amusing Freudian slip, to be sure.

Seriously, I'm no fan of the FDA. There are plenty of very effective and quality-of-life-improving drugs that have been pulled from the market either on the FDA's order or due to FDA pressure because they had side effects that killed a few of the people who took them. Drugs for diseases that affect fewer than a few thousand people are practically impossible to develop because the cost of getting FDA approval exceeds the revenue that's ever likely to be generated. I'm not convinced that it should be the government's job to set down a one-size-fits-all formula for what level of risk the public is willing to accept.

[ Saturday, March 31, 2007 13:22: Message edited by: Thuryl ]

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Really anticipated ideas for A5?? in Avernum 4
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Member # 869
Profile Homepage #95
quote:
Originally written by Synergy:

Oh please. Anything besides point and click. Mouse usage = carpal tunnel and cursage.
And now you know why they call it a mouse cursor.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
Are Drakons superior beings? in Geneforge 4: Rebellion
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Member # 869
Profile Homepage #297
quote:
Originally written by Meta-Undead Spokesmage:

The Shapers did come up with something better. They created new things instead of adding unpredictable and unreliable power to old ones. The creation of new things, not the altering of old ones, is, in and of itself, a sign of superiority.
That's one view. Others might say that pursuing novelty for the sake of novelty is a sign of decadence.

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00
[GF3] Tips for higher difficulty settings? Also, batons and Daze? Also, tip @ Rahul. in Geneforge Series
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Member # 869
Profile Homepage #18
quote:
Originally written by Hawkwind:

In G3 the way status effects were implemented was changed somewhat, and Glaahks cause slowing rather than stunning. The same is true of G4.
It's not true of G4 -- Glaahks have definitely gone back to stunning.

(Of course, because of the new AP system they're questionably useful in G4 as well.)

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The Empire Always Loses: This Time For Sure!
Posts: 9973 | Registered: Saturday, March 30 2002 08:00

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